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US20060270671

Hi BI, nice IKK inhibitors. These seem to hav evolved from alcohol hits first published in that ’03 application, which led to these aminoalcohols (WO2005056562). Resolution huh? via lipase mediated...

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WO2007006926

Just another pyrimidine series? Maybe, but Sanofi-Aventis has a bunch of these sulfonamides in WO/2007/006926. They’ve got an IKK collaboration Millenium with “MLN0415“ a phase one inhaled IKK-beta...

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IKK-b or Jak?

So Merck’s got WO/2007/061764 and the wordplay makes me think the bit about JAK is just a diversion and that the primary target is IKK-b.  You have to squint a little to see the similarity with the...

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Wyeth’s IKK candidate

US20080262010: D-glucuronate US20080262009: acetate US20080262008: succinate Posted in IKK, Wyeth

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MLN-0415

Millenium’s beta-carboline’s aren’t new, but the structure of the Phase one IKK-B inhibitor hasn’t been released afaik.  Currrently in the Takeda pipeline via last years takeover. WO/2009/054970...

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